产品货号：
Z24237
中文名称：
PRDX3抗体
英文名称：
Anti-PRDX3 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PRDX3 Antibody |
| 指标别名 | Antioxidant protein 1;AOP 1;AOP1;HBC189;MER5;Peroxiredoxin 3;Peroxiredoxin III;PRDX3;PRO1748;Protein MER5 homolog;Prx III;PRX3;SP 22 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC,ICC/IF,FCM |
| 基因名称 | PRDX3 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human Peroxiredoxin 3 recombinant protein (Position:T110-Q256).Human Peroxiredoxin 3 shares 93% amino acid (aa) sequence identity with both mouse and rat Peroxiredoxin 3. |
| 实际分子量 | 26KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt,-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | PRDX3(peroxiredoxin 3) also known as AOP-1,MER5,SP-22 or PRX3,is localized exclusively in mitochondria.The deduced 256-amino acid human AOP1 protein shares 86% amino acid sequence similarity with mouse Aop1,and significant similarity with both the human proliferation-associated gene A product and the mouse stress-induced peritoneal macrophage protein Msp23.The PRDX3 gene is mapped on 10q26.11.Expression of PRDX3 is induced by MYC and is reduced in c-myc -/- cells.Chromatin immunoprecipitation analysis spanning the entire PRDX3 genomic sequence revealed that MYC binds preferentially to a 930-bp region surrounding exon 1.Results using mitochondria-specific fluorescent probes demonstrated that PRDX3 is essential for maintaining mitochondrial mass and membrane potential in transformed rat and human cells.These data provided evidence that PRDX3 is a MYC target gene that is required to maintain normal mitochondrial function. |
| Uniprot ID | P30048 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | peroxiredoxin 3 |
| 蛋白名全称 | Thioredoxin-dependent peroxide reductase,mitochondrial |
| 推荐稀释比 | Western blot(WB) 1:500～2000Immunohistochemistry(Paraffin-embedded Section) Immunocytochemistry 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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